MRI scanners have measurable differences between units, even for exactly the same make/model. Unfortunately for clinical research, that means that we might be learning more about which hospital is which than any actual disease phenotype. Harmonization is the process of removing these unwanted site/scanner-wise signals.
As it turns out, this is a specific case of a general representation learning problem. Our work has provided a [deep] variational solution to this problem, and, using begun exploring this method’s use in harmonizing MRI, starting with multi-site HARDI (diffusion).
Publications:
Publications: